diff --git a/flask_cors/core.py b/flask_cors/core.py
index 1eeb20a..acab973 100644
--- a/flask_cors/core.py
+++ b/flask_cors/core.py
@@ -5,6 +5,7 @@
 from collections.abc import Iterable, Mapping
 from dataclasses import dataclass
 from datetime import timedelta
+from ipaddress import IPv6Address
 from typing import Any, TypedDict, Union, cast
 
 from flask import Blueprint, Flask, Response, current_app, request
@@ -508,6 +509,21 @@ def _resolve_patterns(patterns: Iterable[ResourcePattern], *, ignore_case: bool)
     return [_resolve_pattern(p, ignore_case=ignore_case) for p in patterns]
 
 
+def _resolve_origin(origin: ResourcePattern) -> ResourcePattern:
+    # IPv6 URL brackets delimit a host, not a regex character class. Restrict
+    # this exception to complete literal origins; regex origins still compile.
+    if isinstance(origin, str):
+        match = re.fullmatch(r"[a-zA-Z][a-zA-Z0-9+.-]*://\[([0-9a-fA-F:.]+)\](?::[0-9]+)?", origin)
+        if match:
+            try:
+                IPv6Address(match.group(1))
+            except ValueError:
+                pass
+            else:
+                return origin
+    return _resolve_pattern(origin, ignore_case=True)
+
+
 def serialize_options(opts: Mapping[str, Any]) -> _ComputedCorsOptions:
     """
     Normalize a raw options mapping into a strongly-typed :class:`_ComputedCorsOptions`.
@@ -537,7 +553,7 @@ def serialize_options(opts: Mapping[str, Any]) -> _ComputedCorsOptions:
             "http://www.w3.org/TR/cors/#resource-requests"
         )
 
-    origins = _resolve_patterns(sanitized_origins, ignore_case=True)
+    origins = [_resolve_origin(origin) for origin in sanitized_origins]
     allow_headers = _resolve_patterns(sanitize_regex_param(opts.get("allow_headers")), ignore_case=True)
 
     methods = flexible_str(opts.get("methods"))
diff --git a/tests/extension/test_ipv6.py b/tests/extension/test_ipv6.py
new file mode 100644
index 0000000..029e404
--- /dev/null
+++ b/tests/extension/test_ipv6.py
@@ -0,0 +1,49 @@
+import re
+
+import pytest
+from flask import Flask
+
+from flask_cors import CORS, cross_origin
+
+
+@pytest.mark.parametrize("origin", ["http://[::1]:8000", "https://[2001:db8::1]", "http://[::ffff:192.0.2.1]:8080"])
+@pytest.mark.parametrize("use_decorator", [False, True])
+def test_literal_ipv6_origin(origin, use_decorator):
+    app = Flask(__name__)
+
+    def index():
+        return "ok"
+
+    if use_decorator:
+        index = cross_origin(origins=[origin])(index)
+    else:
+        CORS(app, origins=[origin])
+    app.add_url_rule("/", view_func=index)
+    client = app.test_client()
+
+    for requested in (origin, origin.upper()):
+        response = client.get("/", headers={"Origin": requested})
+        assert response.headers["Access-Control-Allow-Origin"] == requested
+    for requested in (origin + "0", "http://[::2]:8000", "http://:8000"):
+        response = client.get("/", headers={"Origin": requested})
+        assert "Access-Control-Allow-Origin" not in response.headers
+
+
+@pytest.mark.parametrize("origin", [r"http://\[::1\]:\d+$", re.compile(r"http://\[::1\]:\d+$")])
+def test_ipv6_regex_origin(origin):
+    app = Flask(__name__)
+    CORS(app, origins=[origin])
+    app.add_url_rule("/", view_func=lambda: "ok")
+    client = app.test_client()
+    assert (
+        client.get("/", headers={"Origin": "http://[::1]:8000"}).headers["Access-Control-Allow-Origin"]
+        == "http://[::1]:8000"
+    )
+    assert "Access-Control-Allow-Origin" not in client.get("/", headers={"Origin": "http://[::2]:8000"}).headers
+
+
+def test_literal_ipv6_origin_without_request_origin():
+    app = Flask(__name__)
+    CORS(app, origins=["http://[::1]:8000"])
+    app.add_url_rule("/", view_func=lambda: "ok")
+    assert app.test_client().get("/").headers["Access-Control-Allow-Origin"] == "http://[::1]:8000"