Pre-registered reanalysis of gut-microbiota-derived TMAO in 750 post-PCI patients. Tests whether TMAO adds information beyond choline, betaine and carnitine for recurrent angina, and whether whole-panel discrimination survives honest out-of-fold validation.
calibration metabolomics batch-effects gut-microbiome pre-registration atherosclerosis cardiovascular-disease decision-curve-analysis biomarker-validation angina clinical-prediction-model tmao trimethylamine-n-oxide microbial-metabolite choline-metabolism carnitine-metabolism targeted-metabolomics
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Updated
Sep 12, 2026 - Python