rpact: Confirmatory Adaptive Clinical Trial Design and Analysis
group sequential tests for neuroimaging
A Shiny app for graphical multiplicity control
Tutorials illustrating the use of baseline information to conduct more efficient randomized trials
896 tests / 42 scripts validating Zetyra calculators (GSD, CUPED, Bayesian, SSR incl. Single-Arm, RAR, Master Protocol). Replicates 8 published trials (Salk, DAPA-HF, PACIFIC, MONALEESA-7, I-SPY 2, STAMPEDE, REMAP-CAP, NCT03377023) + Leyrat 2024.
Group sequential design bounds.
Covariate Adjustment in Randomized Trials
Derive rejection boundaries for RCTs with inconsistent covariate adjustment
📦 BayesianPlatformDesignTimeTrend: Simulate and analyse Bayesian Platform Trial with time trend
Graphical multiple comparison procedures for group sequential design clinical trials
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